Orsense - Non-Invasive Technologues

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Orsense - non-invasive technologies

Learning Center > FAQ

What are the challenges in measuring blood composition using light?

To measure blood composition optically, one needs to measure light patterns after they intercept blood tissue while ensuring high sensitivity to the measured blood characteristics, and without compromising specificity, i.e. reducing or eliminating the effects of interfering factors. However, when projecting light through a body part, it is difficult to determine what tissue or fluid is affecting the light and to interpret the ensuing measurement. 

How do OrSense’s products overcome this difficulty?

OrSense’s scientists have discovered a way to ensure that their data is based solely on blood characteristics. This technology, patented under the name Occlusion Spectroscopy, is based on the changes that happen in an organ when the flow of blood is blocked (occluded). These changes affect the optical characteristics of blood without affecting the tissue. Upon occlusion, a strong light signal is generated, enabling higher signal to noise ratio. Additionally, the strong Occlusion Spectroscopy signal allows the device to measure light transmission through the finger, ensuring higher sensitivity and specificity.

How does OrSense measure the concentration of a given blood constituent such as hemoglobin?

The optical properties of blood are affected by the concentration of each constituent, and this phenomenon is dramatically enhanced by occlusion. Each combination of concentrations, such as hemoglobin and oxygen saturation, generates a direct and specific effect on the blood optical profile, or “fingerprint”. Each patient data “fingerprint” is thus directly translated by OrSense’s algorithms to a concentration of hemoglobin and other blood constituents.

What makes OrSense’s measurements reliable?

In a statistical evaluation of new measurement techniques, the new method is normally compared to a reference technique by its Standard Deviation (SD) value and Bias (Average Differences). Occlusion Spectroscopy creates an artificial static state of the sampled area by stopping the flow of blood – what we call “artificial kinetics”. Thanks to this unique process, correlating measurements are achieved non-invasively.

What are the calibration requirements of the OrSense devices?

OrSense’s Hemoglobin measurements require no frequent calibrations during the ongoing operation. 

What is the accuracy of an OrSense measurement?

OrSense’s monitoring system achieves accuracy levels similar to capillary point of care devices, as compared to gold standard reference data. This is achieved in a painless and easier to use manner, eliminating patient error that may result from blood and chemistry handling. Accurate performance was demonstrated in the most demanding environments such as acute hypoglycemia. This performance positions OrSense as the leading developer of non-invasive monitoring, according to publicly available data.